Morning peeps 

bad :- still chilly but 1 degree warmer than yesterday day -5 lol.... keep warm peeps.

good :- tidied garden a bit yesterday nd found what would become my Easter ducks.....Weathered vintage ducks with mushroom coloured gingham ribbon....otherwise known as the 2 rusty ducks from me garden with a bow on - to go next to my Easter tree. Ha ha. 

Have as good a day as u can peeps x

Morning,

Bad......just found out my friends brother has 6 months left due to a brain tumour....

Good....watching good morning....and there's a piece about sex in you 80s and how enjoyable it can be....well...that's something to look forward to then!  

Hi Ladies- it's ffffrrrreeeezzzing!!! Think have a bit of a tummy bug as well. Sigh......wish I'd never gone to Canada. Feel so awful this past week that it's frustrating now.

Ok maybe I shouldn't grumble considering I'm not going thru treatment or complications but I've had my share and if I can't grumble on here then where can I?

Going dentist this afternoon which is sheer torture to me but hopefully he can sort out issue and I'll feel human again!

It's very cold and guess it's typical Jan weather. Time is going by very fast - Jan is almost over. Hope this year is a positive one for all on here. Keep warm and keep well.

L

Think you have been through enough to grumble!! Poor you still not feeling good hope your soon feeling better! 

The Good- met the man singing at my 50th birthday party today to arrange what he’s going to sing! My mum has done the invites now I am writing a guest list. So hard to decide who should come and who has drifted away so don’t need to be there! Have asked for no presents but donations to my moonwalk instead! 

The Bad- none except it’s cold again 

big hugs to you all x 

HER2 status can change over time (sometimes due to the cancer itself, othertimes due to treatment).

It makes sense when you think about it.  After all HER2 status isn't an indicator of the presence, or absence, of HER2 receptors as we all have HER2 receptors on the surface of our breast cells.  HER2 status is a 'scoring system' indicating the degree to which HER2 is overexpressed. So the pathologist will actually count the number of receptors on the surface of the cancer cell.  They 'score' it numerically and class a score of 0 or +1 as being HER2-, and +2 and +3 classed as HER2+.

It is known for cancer to change from HER2+ to HER2-, which makes sense, especially if treatment is targetting the HER2 receptors.  It can occur, but is much less heard of, for it to change from HER2- to HER2+.

Not sure why [@Marlyn]‍  would need retested, that suggests they have reason to believe there were errors in the first test, but what would indicate this I don't know.  Normally they perform one test and, if it gives a borderline result, they then perform the FISH test.  But I'd be surprised if they gave the result from the first test and then ran the FISH test, usually your doctor won't hear any results until they have their conclusion (even if this means a delay as they run further tests, as happened with me).  In my case they ran the FISH test because the first test showed HER2+ and they knew it to be unusual for it to change from HER2- to HER2+ so wanted to make sure.

Totally get what Marlyn means about when you read the letter though, it's bizarre seeing it all written down clinically.  Sometimes you do find out stuff you didn't know yet too (exact size of lumps etc.)

Nowadays, thankfully, HER2+ isn't quite the bad news it once was as there are now treatments to directly target that aspect of it.

LJx

Gosh, what a good reply...my surgeon also didn't know why it was being retested, she said it's rare for it to go from neg to pos ( although not unheard of) so of course I went into silly mode and imagined all sorts...then gave myself a smack and shake and put my mrs sensible hat back on.....it is what it is....just got to crack on.....

Hope things are going forwards with you lovely lady xx

Something I cane across which may be interesting:

m.youtube.com/watch

Mrsfingers - really helpful to know that your sensation returned in 4 months.  The docs and nurses have said it could return but no-one pinned it down to a timescale

I know we are all different but I always deal better knowing roughly how long, it must have been really hard for you thinking it was permenant.

A