Effects of coming off tamoxifen after 10 years

Hi, I came off tamoxlfen in July after 11 years, I’ve not had any of the many other side effects mentioned. I am 58 and tamoxifen through me into menopause at 46. Since coming off tamoxifen I feel permanently exhausted and have what I can only describe as brain fog, I can also burst into tears in a second at ridiculous things. I was wondering if anyone else has felt like this.

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  • Hi, I'm new on here. Like the original post,  I started taking tamoxifen 11 years ago, same age etc...I feel fine and settled when taking it, no hot flushes,  mood OK etc, but within weeks of not taking Tamoxifen, I literally cry at everything that is remotely emotional,  now I am a soft person but even for me, that's unusual,  anyone else the same? Any recommendations on other medication? Stay taking tamoxi en? I'd prefer not antidepressants and stay taking this! Thanks in advance ️ 

  • Hi, really sorry to hear how youre feeling. All of our situations and Cancers are different in their growth factors etc so i would talk to your Oncologist/breast care nurse (or ask GP to refer you if you're discharged now) as I recall the risk of endometrial cancer increases if being on Tamoxifen circa 10+ years.

    Im a very emotional person but was before Cancer. I did go on antidepressants for a short time during one low period but they impacted my sleep significsntly and made me a bit "numb" emotionally which wasnt me so I came off them. But I have friends who take antidepressants regularly and they dont get those side effects and feel calmer. It always amazes me how our bodies can all react so differently

    I had counselling which was hugely helpful. Key was a counsellor I really trusted and opened up to about all my fears and worries. I can still hear his wise counsel in moments I need to refocus on keeping myself well

    Im mid 40s now but my periods came back after finished 10 years of Tamoxifen 3 years ago and I think my hormones are in a constant flux. I now get bad pmt sometimes which I have never had.

    Healthy eating, exercise, investing in great friendships with close family and friends and trying to manage reasonable boundaries at work keep me sane and help me through and dips in wellbeing.

    Sending you love and hope you find a combo that works for you  

  • Thank you for your message and advice.

    I am pretty active too and you're right it does help!

    1. Sending you best wishes too as we navigate through our female hormones and life
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