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Anyone receiving Denosumab XGEVA

Farmer_Ed

Is anyone here receiving Denosumab XGEVA for metastatic bone cancer

Ive been advised to have this by injection  to slow the progression of the cancer and prevent bone fractures.

Id like to know how well it is tolerated and what side effects you have experienced.

Thanks in advance

Ed

  • Offline in reply to leelaloo

    Morning Lee and Ed 

    great to hear you are doing well Lee and hope it continues.   Sorry to hear you have painful gout Ed and hope it sorts itself out.

    i am doing ok and have a CT scan in January and hope that the cancer is still stable.  

    Hone you all have a great Christmas x

    Cosmopolitan

  • Offline

    Hi Ed

    I had 3yrs of Denosumab injection but had to stop after issue with tooth extraction.please make sure you have a full dental examination and discussion with your dentist. Advise them you are going on this treatment.

    With any dental treatment other than clean or checkup you will need to stop the Denosumab for a couple of weeks and keep your. Oncologist up to date.

    Really important as I now have mronge of jaw.

    Not nice.

    I wish you well with your treatment. 

    Anything that helps and hives you help can only be a good thing.

    Best Wishes

    Lorraine

  • in reply to leelaloo

    Hello Lee

    Nice to hear from you and that you are living life with cancer and all its impairements to the full. The cancer in my bones is being held in equilibrium by the immunotherapy and denosumab. I'm going to have a scan on my head as I've recently been getting migraine headaches, the flashing lights and greyed out vision type but without headache. Never suffered from headaches until now. My Oncologist says that they could be caused by the immunotherapy as there is more evidence arising that immunotherapy can cause neuorological side effects. I'm just hoping that cancer has not spread to my brain, however the mantra one day at a time still applies and I will cross that bridge if the day comes.  I hope that your scan shows good results, it is always an extra layer of stress awaiting the results.   

    The post I answered to LcHawkhead54 worried that pain in big toe could be cancer (and it could), was that having suffered gout attacks myself the symptoms described were exactly that of gout especially the excruciating pain (caused by the sharp needle like uric acid crystals in the joint) plus the fact their GP had taken a test for uric acid.

    I do get occasional gout attacks last one about 6 months ago, always in same big toe. I also have hit on cherries as both a preventative and partial cure along with the usual anti inflammatory Naproxen. I drink a small glass of cherry juice every day and eat cherries when they are available. Also I keep well hydrated, I moderate alcohol (esp red wine) red meat and shellfish not hard to do as they are so expensive. I don't get attacks frequently enough to take allopurinol, which I'm told is very effective. 

    We have a tree, first time in years and Chritmas decorations.Our children and small people will visit Boxing day. Looking very much forward to it. Wishing you and your family a lovely time over Christmas.

    Ed

  • in reply to Lorrainemargaret

    Hi Lorraine

    Thank you for your reply, Ive been on Denosumab 6 weekly for around 8 months now with no noticible side effects. I had a dental check up and xray at the hospital before starting the treatment which showed no problems. I am extremely susceptible to necrosis of the jaw as I had radiotherapy to my jaw and neck 10 years ago and now an increased chance from the Denosumab. Ive been using prescription high fluoride toothpaste Colgate Duraphat for the last 10 years to reduce dental caries and the possiblity of requiring a tooth extraction. A family member jokes I'm lucky having cancer as I get free toothpaste. As you point out the dentist can do checkups and a clean at the hygeinist. Ive been told that extractions and other work needs to be done at the hospital. I did not know that Denosumab had to be discontinued at this point but I guess that makes sense. I hope that you are getting on Ok .

    Ed

  • in reply to Cosmopolitan

    Hi Cosmopolitan

    Good to hear from you and I hope your return to work has gone smoothly and you are enjoying life. Also hoping that your forthcoming scan shows that your cancer is on hold. For me cancer is being kept at bay mostly, a slight increase in back ache but still enjoying life to the full. I also still do some work (3 to 4 hours daily) as Ive worked since 15, it helps me keep fit and with a semblence of normality, which in turn keeps me sane and not dwelling on cancer.

    I don't have gout at the moment, it was a post by LcHawkhead54 that led me to reply to them that their symptoms were classic indicator of gout, having experienced them myself. 

    Wishing you a lovely Christmas 

    Ed

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