Fed up with medication, want a break

I'm a 64 year old man, 5 1/2 years since diagnosis for locally advanced prostate cancer.  Two rounds of radiotherapy failed to eliminate it, and since October 2025 I have been back on hormone therapy.   I am otherwise extremely fit.  I resisted the injections, and have been prescribed Relugolix and Apalutimide.  I should be pleased that my PSA level is <0.1, and I have none of the common side effects.  But it still feels like the medics are playing 'Jenga' with me, giving me drugs that rot my  bones and muscles before the cancer gets a chance.    They make passing comments, 'keep you active as long as we can', but I know my brother who died after 10 years of treatment for PC gave up riding a bike as he feared his bones would crumble.   The worst thing is that I have lost my emotional equilibrium - I spend days feeling like I want to cry.  I used to be resilient, and coped with everything.  I coped with the cancer until very recently - and it is not the cancer that is getting me down, its these drugs, and the realisation that I'm stuck on them forever, or until they stop working.   I am planning to give myself a break for a month. [I get a prescription for three months at  a time] - I know the official answer will always be 'you shouldn't' - and I understand why that is the sensible answer - but what will happen if I do take a break?  [I know that 'PC' will almost certainly be in my death certificate - and if taking a month off the drugs from time to time only shortens my life expectancy a little, but cheers me up, I reckon that's not a bad deal.]  Any honest answers out there?

  • Hi MrSplodge.  I think if you want to take a month off medication, take a month off.  You have to have quality of life and if it makes you happy do it.  This of course is only my opinion and I am in no way medically trained.  I just feel that is won't shorten your life expectancy significantly and it is your body and your choice.  I know what you mean about the medication for life bit, I have secondary breast cancer with bone mets everywhere, with spine being the most painful.  You have to do what you feel is right for you.  Good luck with your choice.

    Lee x

  • Hi Mr Splodge and thank you for your post.

    I am sorry to read that you have prostate cancer and I am sorry to learn that you feel the treatment is getting you down. This must feel very frustrating at times.

    Feeling low or tearful is a known effect of long-term hormone treatment, but there is mixed evidence that taking breaks from hormone treatment reduces these side effects. Some men can feel better during breaks off treatment whilst others do not notice any changes. More research is needed.

    At present the National Institute for Health and Care Excellence acknowledges intermittent therapy as an option within long‑term hormone therapy, for some men with prostate cancer, provided this is agreed upon by your hospital specialist with clear monitoring and agreed criteria for restarting treatment (NICE NG131, 2019). In this context, it is considered a patient‑centred adjustment balancing disease control with quality of life.

    NICE believes in the benefits of shared decision making. It empowers people to make choices about their treatment and care that are right for them at that moment. This includes deciding to continue with their current treatment or to have no treatment at all. 

    I cannot advise you on what to do with your medication but I would advise you to speak to your hospital specialist about how you feel and about your proposed plan to take a break from taking your hormone therapy.

    Any decision about taking breaks needs to be made carefully, with full understanding of the risks and benefits, and with the support of your hospital team.

    Please get back to us if you need any more information or support

    It might help to talk things through with one of our nurses on the helpline. You can call for free on 0808 800 4040, Monday to Friday, 9am to 5pm.

    I hope you come to the right decision and feel better soon.

    Kind regards

    Tina