Anyone had negative biopsy following “grade 5” MRI (prostate

Hi all, 

hope I'm in the right place here 

 

my partner has a PSA level of 0.48 which is normal, however after an MRI they said they'd found a "sinister" looking mass. Seemingly confined to the prostate. My partner had a biopsy last week but I'm looking for similar stories as whether others have looked like very sinister on MRI but come back negative for cancer? 
 

thanks 

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  • Hi Hollie995.  Welcome to the forum.

    I am not a doctor and I have no medical qualifications.  I had a radical prostatectomy for early stage prostate cancer just over 10 years ago, and since then I've been involved with a local prostate cancer support group.

    To the best of my knowledge, performing an MRI before biopsy is a relatively recent development and has only become widely available in the last few years. This is due to the development of the "multi-parametric" MRI (often abbreviated to "mpMRI").  Whilst I am sure that there are men who've had a suspicious lesion identified which was later proved clear after biopsy, I'm not sure that the statistics are easily available.  The relative novelty of the system would make such stats unreliable.  However, you could try conducting your own searches, being sure to include "mpMRI" as a search term.

    At 0.48, your partner's PSA is very low - mine was 5.6 at diagnosis, and most men have a PSA higher than this.  This is a hopeful feature; if the diagnosis should be bad news, then the low PSA and the mass being confined to the prostate should mean there is a very good chance that it's been caught at an early and curable stage. 

    If I might ask, with such a low PSA why was your partner referred at all - presumably there were other symptoms? 

  • Hello, can I please ask you.  My dad had a biopsy the other day.  His score from the mri was 4 and 5.

     His  pas is 9.23.  My concern is he raised this to his doctors last May 2020, they done a full blood test but no psa at the time.  Just worried he has had this already for at least a year and a half.

     

    could the biopsy still come back as negative, something else?

    just waiting for the results now.

     

    many thanks

    jack

  • Hi Finn1707.  Welcome to the forum.

    Let me remind you I'm not a doctor and this is only information I've picked up over the years.

    A PSA of 9.23 is still relatively low, but a PI-RADS score of 4 or 5 is worrying.  The best imformation I can find indicates maybe 15-20% of men in this position don't have cancer, but something else.  There is some room for hope, but I think it would be wise to prepare for cancer.

    If it is cancer then it's probably still early and can be cured by appropriate treatment as I explained above.  However, things will be a lot clearer after the biopsy results become available, with the Gleason grade being the most significant.

    Please come back if you have any other questions.

     

Reply
  • Hi Finn1707.  Welcome to the forum.

    Let me remind you I'm not a doctor and this is only information I've picked up over the years.

    A PSA of 9.23 is still relatively low, but a PI-RADS score of 4 or 5 is worrying.  The best imformation I can find indicates maybe 15-20% of men in this position don't have cancer, but something else.  There is some room for hope, but I think it would be wise to prepare for cancer.

    If it is cancer then it's probably still early and can be cured by appropriate treatment as I explained above.  However, things will be a lot clearer after the biopsy results become available, with the Gleason grade being the most significant.

    Please come back if you have any other questions.

     

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