Anastrozole - ugh!!!

After having stage 2 hormone receptive cancer, I had a lumpectomy and radiotherapy in 2016.

Facing up to cancer and the surgery were a piece of cake, compared to the side effects of the medication.

I started off with Letrozole and put up with the side effects until one night near Christmas, I was pacing the freezing cold conservatory floor, to ease the itchiness and bright red soles of my feet, to no avail. Eventually, I was seen by Oncology and changed to Anastrozole.

Although better, the joint pain, dry nose canal & nose sores, dry mouth and teeth/gum damage, excessive sneezing and runny nose (despite it being dry!!!), anxiety, depression, weight gain, higher cholesterol, skin itchiness and irritation, frequent bladder infections and finally, such horrendous vaginal dryness and vulva pain (I cannot even insert a 'yes' capsule without it being agonizing) and the fact that I have physically been unable to make love with my husband for over a year, enough is enough. I am 57 and want a life!!!

I now have to have bladder surgery, which I am convinced is due to the fact that the Anastrozole is drying my body out on the inside and I feel like an old, depressed, unfit lady, who used to be fit and a happy bunny, but can now only do gentle swimming (i've been told I am lucky to be able to do that!!!!).

The Oncologist/GP and Pharmacist have suggested changing brands, but none of them have taken responsibility for this and I have been left as the 'man in the middle', desperately trying to sort this out, when I am the patient!!

Cancer truly sucks and now that the yearly follow-up appointments with the breast care nurses and Consultant have have been pulled in the UK, i'm sure i'm not alone in feeling totally let down and left to sort myself out re the ongoing 10 year medication regime.

I have taken myself off Anastrozole now and have done so for the last month. Have I done the right thing - who knows, but I can't stand it any longer.

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  • hi I'm sorry to hear of your horrible side effects from this medicine I would ask your doctor change to a different one there's quite a few to choose from and if nothing works you can have intravenous I've recently started letrizole and don't feel any different probably the side effects may come later or hopefully not at all we'll see I hope you're feeling better soon 

     

    best wishes marie x

     

     

     

  • Hi Marie

    Thank you so much for your kind reply.  I was previously on Letrozole, which in itself was awful.  I think though that the Anastrozole is doing more damage internally, which is why it's not so noticeable on the outside.

    To be honest I've given up with the GP, actually GP's and the Oncologist!!!!  No sympathy re the symptoms and it wasn't sympathy I was looking for, just desperate for some relief.  I've seen more than one GP at my local surgery too, to no avail.  It took so much courage to tell a female GP that I physically cannot make love with my husband anymore and that he can't even touch me 'there', because I feel like it's "dried up and gone away" and she didn't even make eye contact with me, nor comment, she just changed the subject.  I have had soooo  many bladder infections and now need surgery and almost 11 months of treatment to repair the damage.  I am convinced that the drying out of my sexual organs has now affected my Urethra and hence the ongoing bladder problems I am having, but of course, no-one wants to address the cause, ie, whether or not it is the Anastrozole that is doing this, but from reading other comments on the forum, I am personally convinced it is. 

    Just feel sooooo alone.  Desperate to wee 24/7, but can hardly go, so am exhausted through lack of sleep and feeling so uncomfortable all the time, but will try to be patient and hang on until my surgery date comes through.  Very hard when you have to go to work and you're exhausted before you get there........................ oh and by the way, I asked one of my GP's for a certificate for a couple of extra days off during one infection, just so I could catch up on sleep before returning to work and she said "you're pushing you're luck" before giving me the certificate.  I felt like a naughty school girl, when in all honesty, I asked out of desperation ....................

  • hi I think you really need to speak to your doctor and keep on at him to change to another medication there is a few to choose from and keep on at them until you are happy they have a duty of your care and it isn't fair to make you suffer like you are like I said you can come off the tablets and have Intrevenious option every 3 months I think the vaganial drying is the through the lack of estrogen the female body doesn't like been estrogen deprived you can buy some artificial vagainal lubrications over the counter or online from Anne summers to help yourself and husband to be intimate again .

    best wishs Marie x

  • Hi Marie

    I have tried several lubricants and have been advised by my GP not to use KY, or water based ones and that the 'Yes' ones (supplied on prescription) are suitable.  They do seem to be very good, but again, administering them is so painful, just inserting the tiny/slim capsule is almost too much to bear and leaves me in so much pain.  This doesn't solve the problem externally either .......

    I will see my GP next week, my husband insists I have one last try to try and get help (just for the record, he is fabulous and so understanding), but it will literally be the last time.  I just can't take anymore fobbing off ......

    Thank you Marie and best wishes to you too and I hope your intravenous option continues to work well for you.

  •  these doctors haven’t got a clue I’ve had the same problem you tell him about some problems you’re having pains and aches you’re not the only one that’s what my doctor said to me ! He is not taking these tablets for years in the end they haven’t got a clue what the pains are like  I do wish you get better and hope the surgery goes well, x Gina 

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  •  these doctors haven’t got a clue I’ve had the same problem you tell him about some problems you’re having pains and aches you’re not the only one that’s what my doctor said to me ! He is not taking these tablets for years in the end they haven’t got a clue what the pains are like  I do wish you get better and hope the surgery goes well, x Gina 

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