Hi all,

Going by the lack of replies, eye issues have not been documented in the Uk in relation to aromatise inhibitors such as Letrozole.

I have been taking Letrozole since August 2019 when I was diagnosed with breast cancer and apart from severe arthraglia have managed to keep fairly well. 
Unfortunately I precently developed Macular Eodema and am receiving a monthly injection in my eye. This is usually associated with diabetes but I am not diabetic so did some research and found that in the USA and Germany macular eodema is considered a very rare condition for non-diabetics but is associated with aromatise inhibitors. 
I have passed this information on to my local breast cancer clinic and oncologist and ophthalmologist and none had heard of it. Makes me wonder if professionals actually read relevant research papers.

Hope that you have fully recovered from your eye issues, mine are ongoing.

best regards

Phebie

Hi 

I have recently been diagnosed with a retinal membrane.  Basically a membrane behind the eye that feels as if you are looking through cling film.  I was told this was often age related.  I also had very dry eyes and knew this could be caused by Letrozole which I have been on for 3 years.  I asked if Letrozole could cause any other eye problems and was told no.  However I have just recently found a medical research paper which states that Letrozole can cause the pulling of the vitreous in the eye on the retina causing the retina to thicken and changing vision.

So I agree Doctors don't always seem to know the different side effects or don't want to tell us.   

Best Regards

Hi I’ve been taking letrozole for 5 yrs now and have been diagnosed with the pulling of vitreous in my eyes . I have an appointment at the eye hospital on Monday and will make sure I mention that letrozole has been found to  cause this . The opticians said it was age related and didn’t connect it to the medication . Should I stop taking letrozole ? 

Hi I’ve been taking letrozole for 5 yrs now and have been diagnosed with the pulling of vitreous in my eyes . I have an appointment at the eye hospital on Monday and will make sure I mention that letrozole has been found to  cause this . The opticians said it was age related and didn’t connect it to the medication . Should I stop taking letrozole ? 

Hi, 

Hope you go on okay at the eye hospital....please give us all an update...I'm very interested in this.   I was at the opticians for 1.5 hours and he did every test he could including the retina photograph and could find nothing wrong. My eyesight is definitely not right though. I'm 49 next week and never had eye problems before.

I've to go back on 31st March to see senior optometrist..

You've been taking Letrozole much longer than me ..I've been told I'll be on it for 7 years...I don't know if things return to 'normal' when we stop taking it...

I've actually forgotten what 'normal' was like!

Good Luck x

Hi , had my hospital visit today. 4 in depth tests which resulted in the same info as the opticians gave me . I mentioned the research paper on vitreous gel and letrozole but the consultant said she hadn’t come across or heard of this connection. Mainly said it’s age related . I’m still not sure too much of a coincidence tbh.

Has anyone else heard anything different? 

Hi, 

Thanks for your reply.  My appointment on 31st is back at the opticians so I don't expect to come away with any more information but I will be asking if he's heard of the connection with these types of drugs.

I just want to understand what's happening, it's disconcerting that something seems to be throwing my vision/focus out...Incidentally, my Breast Cancer Nurse hadn't heard of it because I asked her last week.

Best wishes.