Hi, I'm being treated for secondary breast cancer, firstly with chemotherapy. I had 4 sessions of A/C (every 3 weeks) which was pretty tough and now 12 weekly sessions of Paclitaxel. I am about to have round 10 so only 3 left to go and counting! In some ways the Paclitaxel is much easier than the A/C but I think the secondary effects are culminative. What I really wanted to ask is if anyone else on this regime has had terrible itching to the knuckles and backs of the hands causing skin colour changes (mine are red/purple now) and also peeling skin?The oncologist has given me anti-histamine tablets and also a corticosteroid cream which I had to stop using after just 1 day as it felt as though it was burning. Some days my hands feel like they're on fire and whatever I put on them to try to ease the soreness/pain doesn't seem to work for very long. I have tried natural remedies like the gel directly from the Aloe plant but had to stop as it caused severe dryness. At the moment I'm using Zerocream which I'm tolerating better than any of the others I've been given/recommended.  It would be good to know if anyone else has experienced this and if they were able to ease the symptoms. Many thanks.