I have had 35 cycles of pembrolizumab finishing in November 2018. I was not allowed to continue after that on a clinical trial even though it was allowed for in the trial protocol, If you click on my posting history you will see the details.

The short answer is, nobody knows what the optimum number of cycles are. Merck for example, the manufacture of pembrolizumab 'recommend' a maxamimun number of 24, this ties in with keeping it cost effective for the NHS. However, they still have people from their fisrt clinical trial still taking it 8 years later.

I have had 35 cycles of pembrolizumab finishing in November 2018. I was not allowed to continue after that on a clinical trial even though it was allowed for in the trial protocol, If you click on my posting history you will see the details.

The short answer is, nobody knows what the optimum number of cycles are. Merck for example, the manufacture of pembrolizumab 'recommend' a maxamimun number of 24, this ties in with keeping it cost effective for the NHS. However, they still have people from their fisrt clinical trial still taking it 8 years later.