Anastrozole has ruined my bones.

Hi There

I was diagnosed with stage 2 Oestrogen positive Breast cancer in 2016. After just 3 round of chemo, my ping pong ball sixzed tumour had disappeared and the cancer had left my lymph noed. After 8 rounds a mammogram had showed that though I was clear, calcium depositis on my breast might flare up into cancer and so I had a full mastectomy of the right breast and had 14 nodes removed. The nodes came back clear and the breast was cancer free though I did have dome precancerous tissue. I had had a complete pathological response which considerably increased my odd of not having a recurrence, After some months I had my healthy breast reduced from an f to a c cup to match my new implant and the removed tissue was completely cancer free. I then began anastrzole with zoladex injections to stop my periods. I also took part in the palbocciclib trial from 5 cycles until it caused my to reject 2 implants and developed sepsis.  

After a year on Anastrozole a dexa scan showed that I had gone from moderate osteopenia -1.7 to osteoporosis -2.6. I was horrified. I asked the oncologist what my chances of recurrence were. She said 5 to 10% if I take the anastrozole and 7 to 10% if I take nothing.  So I stopped taking it. I worry that I have gone against my oncologist but if I keep taking that drug I reduce my chanced of recurrence by 2% but will definitely ruin my bones. I haven't told my oncologist yet

  • This is such a great site. I am walking more. Started back doing yoga twice a week. I am 63 before I stopped taking anastrazole I felt a lot older pain hips arm hand. So down would cry everyday.Live today tomorrow can look after ITS self.

  • I love it!!!!  We each intuit our own lives.  At 73, all insurance has been cleared, the process of reconstruction begins 3/25!!!!  My rt breast mastectomy was 12/12/14 and I did not need two breasts until now.  Cancer free, so many irons in the fire, I love my life....Tomorrow will take care of itself....

  • Im happy to see a positive on here, Id come looking for some tips about anastrazole, which oncologist gave me last week, on the Wednesday, Id started going down with what has turned into a monster chest infection, and because Im also on meds for Behcets disease I had to lay off my methtrexate as you cant take that with a chest infection, and Im on antibiotics.

    I wanted to get some feel for what its like to be on anastrazole as work expect me back from 17/2. Ive been feeling totally battered first by the dx in late October, then surgery 3/12, then chest infection late January. Im full of arthritis and have hip replacements, a mid foot fusion, and fused ankle, and my toes have all been unbuilt and rebuilt. I get horribly breathless due to Poland syndrome which means my rirbs go in instead of out, and frankly, Im wondering how the hell I will make it til 66 to get my OA pension (Im 61 and got medically retired from my former job 15 years ago, on a pension) I like my job, providing support for disabled uni students, but its a gig economy type post, it involves travelling by bus to varied locations, and lugging a laptop or pile of note papers around with me. and Im starting to wonder if Im up to it. already one of the other jobs I do there has pulled my bookings cos they are worried it would be too much for me to do a full day shift recruiting candidates, and I know they are right. it would atm.  but on top of all this, I have no idea of how to pace myself., Ive been on heavy duty steroids and methotrexate for the last 17 years, and Im terrified of the potential bone damage from anastrazole, although the oncology guy was brilliant and said if I get any bone issues he wants me to ring his secretary and book in to see him. Im amazed cos it took 6 years to get my most recent dexa scan done and that was only because I requested it.I suspect  theyd forgotten to do it.Does anyone else feel like its too much to expect a person in this situation to try and keep on working??

  • I was 68 when I had my right breast mastectomy, I'm now 73, cancer free and starting my reconstruction.

    i was so exhausted and hurting while on Anastrozole, I was just grateful to sleep 24/7.  I stayed on anastrozole for 2 1/2 years with a self imposed break after two years. Finally decided I did not want the pain....I could not have worked.  Now I'm amazing.  No guarantees in life, I'm enjoying while I can!!!!

     

    loving thoughts coming to you from Raleigh, North Carolina

  • Wow, love your attitude !  thanks for your reply, Ive been on meds so long (since 2003) from a diagnosis (Behcet's) which is now in question after I asked for a second opinion as there wasnt a rheumy/ autoimmune disease consultant in post since my old one retired 5 years ago, I was fed up with inconsistent approach of locums, and then discovered my records were full of inaccuracies, anyway, now the cancer rush has died down a bit, Im going to ask to go back to the specialists in Birmingham and see what they think I need to do to get off the meds Ive been parked on!  SO Im going to girl up and decide to go on anastrazole, go and get some complementary therapy sessions under my belt, if Im up to it Im off to Birmingham jewellry quarter on Saturday with my newly engaged daughter this weekend to get her engagement ring resizing checked over, and then Sunday is helping husband and son clear the hugely overgrown hedge round the house he moved into last summer.  Ive decided that from now on, Im going to assume the character of a diamond, on the grounds that I'm sort of starting to sparkle a bit after being under several months of intense and horrific pressure.  I love your example of how to rock it after a diagnosis and treatment, even if at times it sucks.  thanks for the inspiration, I needed that !

    all best x

  • I love you "girling up"!!!!  And just collapse and rest when you have to.  Thank you for sharing YOUR trek.  I had monthly 3 day migraines for 40 years, before migraine shots.  So far nothing has hurt that much and I love to be lazy (with an excuse).  you obviously have humor and that is beautiful.  I just met an engineer who studied at Birmingham University so I am kind of feeling the UK Many hugs, and loving thoughts to you and your family!!!!

  • thanks, if you ever vist the UK, make sure to check out Birmingham, it has been radically rebuilt, and has more miles of canals than Venice- if you get to see a tv show called Peaky Blinders its based on the area around Birmingham, its got a fantastic art gallery, jaw dropping modern architecture, and a beautiful botanic garden. the bit I get to go to for the centre is in the rough end of town, when I went in summer, there was a police chase, and a car pulled over with what looked like armed police, which we dont usually have over here...couldnt wait to get back to sleepy worcestershire.

     

  • Thank you, Peaky Blinders is my favorite series, so I have more of a feel.  I really think being interested in life is more than half the battle.  Your daughter is engaged, just telling people the stories of our life.  My mother is 95 living on a ranch in Idaho, I did my chemotherapy there, a fabulous hospital and cancer center.  Then I had to deal with a property in Blythe, CA, with temperatures between 115-125 degrees everyday ( good air conditioning).  So, I had my oncologist in Raleigh, North Carolina, one in Idaho and one in Palm Sorings, CA.  A childhood friend is in his 28th year in a CA prison, so my visits did not stop just because I was bald.  Now I have really unbelievably beautiful thick grey hair.

    I worked in a hospital years ago, supervisor of admitting.  One wife, in her 30's, dying, small children, would use her hospital stays as a romantic time with her husband, complete with a lovely negligee.  Then a 40'ish man with twin girls, one on each knee, he in a wheelchair, would roll into my office to be checked in.  He was so sad to be leaving, but so brave, I think that really imprinted me.  My daughters were with me when I had a breast removed and they just kept me laughing.  Your children and mine are being taught by us how to LIVE!!!! 

  • wow, thanks for that- we do get imprinted with how to survive dont we, hope I have passed that onto our kids.  My dad was 100% war disabled, because he picked up tb and skin cancer serving in the RAF in India during WW2, and even worse, because he was a skilled radio communications worker, they wouldnt demobilise him at the end of the War, they made him and others like him in telecoms stay over there until late 1948 because of the war of Partition between India and what went on to become Pakistan, and the decline of the British Empire "East of Suez"- anyways, it cost him a kidney, his hip joint had to be patched up with  his own bone out of his leg, and one leg was shorter than the other, I got bullied at school due to his disabilities. But he taught me how to get on with life, as did my mum, he spent two years in hospital and she visited by coach every weekend for two years, and saved enough from her secretarial job to buy a house for them in London, as there was no prospect of getting council property to rent.  She said every little girl should learn a four letter word - not rude, the word she meant was COPE she taught me to cope, she coped, he coped, we all did, they had a great life together, 64 years married when she died after suffering a stroke that robbed us of how she really was, as she got vascular dementia following that. Dad went on for 4 years after her, moving to residential care a mile from us, just up the road, until he fell and later went into delirium then kidney failure.  He was 94.  I was worried about telling his big sister (97) in AUstralia, but found out she had died five days before him over there- after having a big family party in her care home, with treats for the great grandkids and drinks for the adults, when they all left, she slipped away.  just like dad.  Lives well lived whatever was thrown at them. thats how I hope my family will think of me whenthe time comes. so next week. stuff thoughts of work, Im off to get my hair highlighted!! have a great weekend.x

  • I read your message. I think it's got be your decision. I found the pain to much. I want my life now. I am 64 this May. Enjoy your life today. All the best to you hugs and kisses sent to you.