Hi Simon, Glad your are receptive to the treatment you are getting. I had similar for breast cancer three years ago. I never experienced any negative reaction and got through it well. I did not have secondary cancer however I did have my treatment with others who had been on Herceptin for over ten years because of lesions elsewhere. So all in all it must be good stuff. Will you continue with the Paciltaxel for a long time or will it revert to only Herceptin. The people I speak about only had Herceptin once their dose of chemotherapy had finished. Warmest Wishes for the future. Anne