Hi Ali, I started on Everolimus & Exemestane nearly 3 weeks ago. After taking just the first tablet of Everolimus I was violently sick for 24 hours. Also had migraine type headaches and insomnia. I started anti-sickness and anti-nausea tablets straight away and it did stop the vomiting, not the nausea but made it tolerable. But the headaches and insomnia continues, along with constipation, shortness of breath and a cough. My oncologist is worried the cough and shortness of breath could be treatment induced pneumonitis but Im waiting to have this confirmed, hopefully tomorrow.  Meanwhile I can hardly walk or talk for very long without feeling like I’m climbing Mount Everest. This is my 4th line of targeted therapy so I think I may be running out of options but unless I can get these horrible side effects under control I will be asking to either have the dose reduced from 10mg to 5mg or change to something else. I have recurrent breast cancer stage 4 metastasised to bones and glands. I am amazed you have tolerated it so long but everyone’s different but you have done very well up until now. Good luck and I hope you can get the side effects under control.