Phesgo and Itchy Skin

Hello Everyone 

This is the first time I have posted on this site.

I have Stage IV Secondary Breast Cancer and (having had 12 weeks of Paclitaxel chemotherapy) am having Phesgo targeted injections (Trastuzumab and Pertuzumab) every 3 weeks and Denosumab every 12 weeks.

The Phesgo targeted therapy is causing severe skin itchiness.  I tried some Fucibet cream which didn’t help and am now using an itch relief cream called Eurax, which is mildly soothing.

I wondered if anyone else has had the same problem and might have found a solution?

if so, I would love to hear about it!  Many thanks.

all the best.

  • Welcome to Cancer Chat Viticella, although I'm sorry to hear about the itchy skin you're contending with as a result of the phesgo injections.

    Hopefully some of our members who have been in a similar position will share their tips and advice with you soon, but I do hope this information we have about dealing with itchiness will prove useful.

    We have a team of cancer nurses available on 0808 800 4040 if you'd like to get their thoughts and advice on this as well. Their phone lines are open Monday - Friday between 9a.m - 5p.m and they will do all that they can to help.

    We're thinking of you Viticella and hope this becomes more manageable soon.

    Kind regards,

    Steph, Cancer Chat Moderator

  • Hi Viticella, sorry to hear that the phesgo is causing you a problem. I have been on phesgo for a few months and get really itchy arms. My oncologist prescribed a cream called epimax and anti histamine tablets, which do seem to help. Luckily it's only my arms that are affected. Hope you manage to find something that helps. Xx

  • Thank you so much, Pippin24, strangely enough, just today my skin seems much calmer, but I have made a note of epimax cream and will ask my oncologist to consider it for me if it flares up again.  Thanks so much for the tip.

  • Hi there.  I finished my targeted therapy (Phesgo) in August 25 after taking it for a year.  I also have been plagued by stinging, itchy rash mainly on my upper arms, sometimes shoulders and back of neck.  Because I have also been taking heart meds (the Phesgo caused reduced heart function) it has been difficult to establish the cause of the rash but I strongly suspect Phesgo.  

    I too was prescribed Fucibet and Xysal antihistamines which did very little to calm it.   I am now using Aveeno gel moisturiser which is more expensive than the body lotion but after daily use for about 3 weeks it does seem to have calmed the affected areas down a lot. I don’t scratch half as much as I did. 
    I’m hoping, as the Phesgo fully clears the system that the itching will clear up.  But I’ve had a full lymph node clearance as well and I read that that, along with the effects of radiotherapy could also contribute to skin problems. 

  • I too have been plagued by severe itching since December 25. I’ve tried lots of antihistamines which didn’t work ….then went onto amitriptyline / -  that seem to exacerbate the itch.  I’m now on pregabalin which may be helping. I finished my injections six weeks ago but the itching is still with me.  Does anyone have any idea how long it takes to go away, after the treatment finishes? 
    thanks  

  • The only thing that seemed to soothe the itching a bit was the Aveeno products   
    Other than that it has simply been a question of time.  Now that I am a year on since my last Phesgo dose my itching has  pretty much stopped. 
    I think it’s just a question of passage of time.  
    I still sometimes experience a bit of itching.  But I guess when you have lots of scar tissue from surgery and then radiotherapy damage on top of that these are all factors which can cause and prolong the itching.  
    the good news is that the passage of time really does help and you start to feel much more “normal “ again.