Denique - bisphosphonates and necrosis of the jaw

Hi, I used to post on this site, but some 5 years later I would like to talk about bisphosphonates.

Shortly after my 6 months of chemo (last 3 months with Paclitaxol - and I can't fault that despite a few problems [and a knowledge of Latin and some tree names...]) plus a minor op and a few weeks of radiotherapy, I was put onto a course of bisphosphonates. I was advised that I should see my dentist as any major work (e.g. extractions) should be done before commencing. I did, and the dentist advised 5 (or 6) extractions. This was early 2020 and I agreed (stupidly as I now think). As we know, Covid hit a little later in 2020 and I was immediately put onto the shielding list, I finally saw a dentist late 2020/early 2021 who referred me to a hospital, months went by and I heard nothing. Contact again and was referred to another hospital. More than 4 years have passed, during which I have had my 2 front teeth drilled away to pegs to take a top set, a set of false lower jaw teeth anchored around a 40-year old crown which was dislodged (and later the remains of the old tooth drilled away) . Yet I am still told that bisphosphonates have a lasting effect...

So my question is - What is the advice about bisphosphonates actually aimed at? Theoretically, as I understand it, as a bone strengthener. But can also cause necrosis of the jaw? 

Science.please (she lisphed)

D xx

  • Yes Denique........Bisphosphonates can cause  necrosis of the jaw.  Cited by www.gov.uk

  • Hello, and thank you for your post,

    Osteonecrosis of the jaw is an uncommon condition. The exact causes are not known. Possible factors that might increase the risk during bisphosphonate treatment are if you have dental work done during treatment. That's why people are asked to get a dental check and get any dental work done before treatment starts. The reason doctors know that it can cause osteonecrosis ( in a very small number of people ) is that studies suggest that nearly all of the people affected with osteonecrosis either wore dentures or had dental treatment in the previous year.

    It might help to read the information we have on our website about how bisphosphonates work and why they are given for breast cancer .

    Please get back to us if you need any more information or support.  You may find it helpful to talk things through with one of the nurses on our helpline.  The number to call is Freephone 0808 800 4040 and the lines are open from 9am till 5pm Monday to Friday.

    Take care

    Caroline