High Grade Cell Changes and HPV

Hi there, I have not been sexually active for many years, and was horrified to find out in a smear two years ago that I had HPV 16. It was monitored, but in March 2025 my smear showed HPV and low-grade cell changes, so I was referred for a colposcopy. The consultant suggested a LLETZ procedure, and when I queried why this was being done for low-grade changes, he said it was because of my age (59), ie I couldn't clear the virus as quickly as someone younger. 

I had to have it done under anaesthetic, as I was in so much pain in the Outpatient clinic that the nurses refused to proceed. I ended up in A&E three days later with faecal impaction causing acute urinary retention, so the whole thing was horrible. I didn't get the results until Feb 2026 and was shocked to read that they found high-grade (CIN 3) changes. I don't understand the change from low grade to high grade. I was also at Gynae Oncology last week for an episode of post-menopausal bleeding (11 weeks after LLETZ) – the consultant removed a cervical polyp, so hopefully that's all it was. I'm just wondering if anyone else has had a similar experience with the low grade to high grade changes with HPV 16, and, if so, did the LLETZ clear the HPV? I will of course have a follow-up smear, which I think will be around June or July, though our services here are very delayed.

Thank you so much.

  • A very warm welcome to the forum Liebe1, although I'm sorry to hear about your cell changes and recent episode of post menopausal bleeding 11 weeks after having your LLETZ.

    Hopefully the follow up smear you're due to have in a few months time will be able to give you some good news but if you'd like to discuss any of this with one of our cancer nurses before then, you can give them a call on 0808 800 4040, Monday - Friday between 9a.m - 5.pm. Using their knowledge and insight they will hopefully be able to address some of your questions and concerns, and ease your mind whilst you wait.

    I hope some of our members who have found themselves in a similar situation will stop by soon to share their experiences and advice but in the meantime, we're sending you all our support Leibe1 and will have our fingers crossed that the LLETZ has been successful in clearing your HPV.

    Kind regards,

    Steph, Cancer Chat Moderator

  • Thank you so much for your kindness x