Confusing - pre cancerous cells showing on smear test but not on vaginal biopsy

Hi, my story is I had a smear test in Nov 2022 which showed severe high grade pre-cancerous cells, I had a colposcopy in December 2022 which showed the same, I was booked in for a LLETZ procedure on 3 Jan 2023, the histology came back clear and I had an appointment to see the consultant a week later, the consultant advised my case had been looked at by the  MDT and they think the pre-cancerous cells may be higher up and they recommended a totally hysterectomy which I had on 28 April 2023, histology came back as normal.  I had a follow up vault smear the end of November 2023 and the results again showed severe high grade pre-cancerous cells and I had a vaginal biopsy on 30 Jan 2024, I've just phoned for the results and they are normal, they are taking the case back to the MDT which is the end of March to discuss next steps.  I'm just so confused about how can the pre-cancerous cells still be showing up but not there on any biopsies 

  • Hi louise2127,

    Welcome to Cancer Chat. It sounds like you've been through quite a bit with all this, and I can understand your confusion about the results.

    I hope that it's not too long for you to wait for any follow-up appointment and for you to get the information that you need about this. It's difficult to advise on it, but as I say hopefully you will get some answers soon.

    You are welcome to post in the 'Ask the Nurses' section of this forum if you'd like to get the thoughts of one of our nurses, though it will only be general advice that they are able to offer.

    Wishing you all the best,

    Ben
    Cancer Chat Moderator

  • Hey. I was just wondering if you have had the 'info' back form the MDT yet? I am rural and the hospital I was/am at, claims it does an MDT every week?! I am still waiting for the MDT to chat about me - 5 months on...... Hope you have had some news.