My spouse was diagnosed with Myelofibrosis in 2018 and whilst initially controlled by drugs, a rapid decline meant he needed a stem cell transplant. This took place in November 2020 with his sister being a 10/10 match. He was doing well and hospital were happy with him until about 6 weeks ago he started to experience extreme bone pain which he also suffered with before the transplant. After a failed bone marrow biopsy ( his bones are like rock and it's difficult to get any liquid/marrow) he had another biopsy on Tuesday where they took the sample from his sternum.

We had a normal clinic appointment on Thursday and were told he now has Acute Myeloid Leukaemia and needs to start chemo straight away. He is booked in for tomorrow for a week of chemo then I'm not really sure what happens after that. I feel like the conversation with the doctor on Thursday has left me know not really knowing what's going on although I know she said if he didn't have treatment he would only have months left. I have tried researching this but can't seem to find anything specific to his journey. 
 

What kind of questions should I be asking the doctors and nurses about this whole process? I very much deal with facts and figures and don't feel like I took anything in we were told but the husband is pretty sure his outcome is grave. Is it possible to have another transplant in one has failed within 10 months? 
 

I'm just a bit lost with it all.

Thanks