Hi CathyD, sorry to hear about your recent diagnosis of grade 3 triple negative breast cancer. I myself had a port fitted in my chest, rather than a PICC line. This procedure is a little more invasive, but involves less maintenance afterwards. I have spoken to others that have had PICC lines put in, without any issues. I have just had my 4th cycle of chemo and haven't had any pain during the administering of it. I have also been pretty lucky so far, having minimal side effects. Everyone is different of course, but there are always people to call should you have any issues. I wish you well on your journey moving forward. X