Hi Daria_S,

Welcome to Cancer Chat. I'm sorry to hear of the difficulties you're experiencing. Hopefully since your post things have eased a little.

Hopefully also you'll get some more replies to your post here soon. There are various other discussions on Letrozole on the forum, so you can also have a search of the forum if you would like to (using the search bar at the top of the page).

Do discuss any difficulties you're having with your doctor too, to see what they may be able to suggest.

Wishing you all the best,

Ben
Cancer Chat Moderator

I was started on Letrozole 12 days ago and have had a mild upset stomach including pain ever since. The pain is not severe but I am conscious of it all the time. I have decided to persevere with it because I have been told that it might settle down after a few months. I think it is a recognised side effect of this drug. I am also feeling drained of energy and a bit low, which is unusual for me. I don't want to change brands at the moment because I had a severe allergic reaction post surgery and my body seems to dislike change!

Did you change your brand? Please let me know if there has been any improvement.

Kind regards

Anne  

Different brands, affect everyone differently. My wife was initially on Letrozole, and didn't tolerate it well at all. The doctor tried her on other brands, each with varying degrees of side effects.  She stopped taking it, and after talking with her oncologist, she was put back on Tamoxifen. My wife is in a weird place with all of this. She's now 54, but because she had some thickening of the womb, whilst they were taking biopsies to rule out the sinister stuff (luckily, it was all benign), they took samples to see if she was pre or post menopause. Her cells came back as pre, but only just. They suspect she is post, and the results came back that way because sometimes they do, but because she couldn't tolerate Letrozole she was just put back on tamoxifen because she has breezed through that medication thus far.

But the long and the short of it all is, your side effect to each brand will be a highly individual thing.

Thank you for the information concerning your wife. I am 81 and have had surgery for breast cancer and the removal of my axillary lymph nodes (of which 4 were cancerous). I understand that for someone whose cancer has spread Letrozole is the preferred treatment alongside radiotherapy which I shall start in two weeks' time. If after a few months I am still experiencing side effects I shall pursue the matter with my oncologist. With all these powerful drugs having different risk factors - bone deterioration or possible blood clots - I think it is probably "Hobson's choice"!