Letrozole - side effects

Since taking Letrozole I have become quite stressy and anxious. I am usually Miss cool, calm and collected. I feel like I have PMT all over again. Had a hysterectomy ten years ago (non cancer related), now age 53. Since then my hormal tantrums have disappeared but seem to have come back since I have been on Letrozole.

Anyone else found this and are you finding ways to deal with it? It is totally not me and I am behaving like a stupid hormonal woman and getting sense of humour failures! I feel embarrassed I am behaving like this. :shocked:

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    Hi Raya,

    A very warm welcome to our forum. I am sorry to hear about the side-effects you are having with Letrozole. How long have you been taking it for and, what type and grade of breast cancer do you have? You might find it helpful to discuss your problems with your breast care nurse, as there are  ways to try and lessen some of these symptoms. If not, there are other hormone therapies which you could try, but they all have some negative effects.

    I too have breast cancer. I've had two bouts in the past 12 years. I took Tamoxifen for the first year and had a lot of side-effects with this. When the second batch was discovered a year later, I took Letrozole for 6½ years. I again had several side-effects, but persisted. I stopped taking this in July 2017 and, am pleased to report tha,t although my joints are still sore and I continue to sweat and feel nauseous, I feel considerably better than I did when I was taking it. The other positive is that I am still here!

    Please let us know how you get on an, remember that we are always here for you.

    Kind regards,

    Jolamine xx

  • Hi I'm taking it and I'm getting terrible sweats all day and night. I already have arthritis in my fingers and it's much worse since taking this. I too feel fed up and miserable but I try and put into prospective why I'm taking it. It's hard isn't it ? 
    Ask your GP if there is anything else you can try. You shouldn't be this bad.

  • I recently started taking Letrizole and have stopped HRT.  I had really bad hot flushes previously which have reoccurred and I think Letrizole may not be helping with this although from past experience know I struggle without HRT.

    Sometimes once you've been medication for a longer spell of time side effects can ease a bit or you may find better ways to help manage them.