I have come off tamoxifen after five years - after discussions with my oncologist, it was decided I could stop as there is now evidence that staying on for ten years can cause other issues like clotting and other cancers. It has now been a couple of months and unusually for me, I feel a very low level of depression. I am wondering if anyone else has experienced this after coming off. I had no issues while I was taking Tamoxifen. I have thankfully never had any mental health problems in my 58 years so this is alien to me. With no other factors involved, I am starting to think it's withdrawal from Tamoxifen. Anyone else?