Hi. I have now taken Letrozole for over 6 years.  I cope pretty well but it definitely affected my moods.  I am a very positive person, was always chirpy and 'seem to remember ' - 'funny' and fun.  I think it's like very serious pmt.  I take a tiny dose of anti depressant venlafaxine which just tips me back to 'normal' mood.  I get twitchy, short tempered and anxious at times and my husband often says why don't I up my dose.  I'm reluctant to do this as if I miss it, even once I feel terrible - physically dizzy etc. So it would mean I can't ever stop it.   But, it is worth taking to counteract moods and the letrozole is something I'm not prepared to stop taking  if it stops, or ups odds to stop cancer coming back.  Letrozole does affect my mood, and also creates issues with libido and other physical effects, but on balance so happy to be able to take it as a prevention measure. 

Hi Janey,

Welcome to our forum,

I just wanted to pick up on what you said about Venlafaxine. As with all anti-depressants, you cannot suddenly stop taking them, but have to gradually reduce the dosage and frequency that you take it for. If you suddenly stop or miss taking it, you will feel absolutely awful.

Kind regards,
Jolamine xx

Hi Janey,

Welcome to our forum,

I just wanted to pick up on what you said about Venlafaxine. As with all anti-depressants, you cannot suddenly stop taking them, but have to gradually reduce the dosage and frequency that you take it for. If you suddenly stop or miss taking it, you will feel absolutely awful.

Kind regards,
Jolamine xx