My husband was diagnosed with CUP in May 2021. Biopsy indicated primary could be lung, liver or pancreas. So far doctors have chosen to treat it as lung, although there're plenty of tumours in the liver and up to the recent scan nothing found in the lung (except for they previously said was scarring from clots in February). No EGFR variations, PDL1 <1%/negative.

2 rounds of GemCarbo and 2 rounds of Atezolizumab after that showed no response. We're currently waiting for the consultant to suggest next steps incl. trials, but expect her not to offer anything further.

I have searched for trials, and although there might be one in London, it excludes previous PDL/PDL1 treatment cases Other trials abroad list the same exclusion. "PDL1 negative" apparently has close to no chance with Atezolizumab, but PD1-targeting drugs could work.

Pembrolizumab aims at PD1. The drug also was approved for NHS England as NSCLC treatment in 02/2021 (article in PharmaTimes).

So, clutching at straws - anyone on here who has had that newly approved drug?