Hi everyone. I've been on Sutent now for 18 months. I'm aware I've entered the zone where I could be told it's not working any more. Sorry if this is an insensitive question, but do symptoms change as it's stopping working? (I have 2 spine mets. I do the 37.5mg course and have been fairly pain free. Also, if I get news that I have to try a second line treatment, is it likely to fail more quickly than the sutent?