Lymph Node Removal - Is my immune system affected?

I recently had a Sentinel lymph node biopsy following a diagnosis of melanoma. Thankfully the cancer had not spread. However, I am wondering if my immune system is affected by the removal of lymph nodes from my groin.

In light on the Corona Virus, and the need to be cautious, this is playing heavily on my mind, and have been trying to find out if I am at more risk now than before I had my lymph nodes removed.

I cannot find any information online. Is anyone able to advise?

  • I can quite understand your worry. I had a complete lymph node clearance from my groin & pelvis (23 in all) so I've always been interested in whether it changed my immune system. 

    Firstly, can I say that a SLNB usually only requires between 1 & 4 nodes removed. Such a small number won't have much of an affect on your immune system. A full clearance, like for myself, will have some affect but not as much as for those who are having/have had chemotherapy as this involves the white blood cells which aren't involved in the lymphatic system.

    From what I've read, to put it into context - the lymph nodes sieve out any nasties in the bloodstream. If the nodes aren't there, the remaining nodes in that particular area have to work much harder to sieve out more nasties than they normally would. This may not work 100% so the immune system will be slightly lowered making the patient slightly more at risk to infection but it's usually an infection in the area of the node removal ie. cellulitis. 

    So, if you have had a small amount of nodes removed you shouldn't notice much difference where coronavirus, seasonal flu etc is concerned. For myself, in the 10 years following my node clearance I have had the flu jab & pneumonia jab. One winter I got flu because it was a different strain to the flu jab - I was very poorly (bed ridden) for 3 days but started to recover & was fine after a week. I'm keeping myself to myself as much as possible at the moment in the hope I don't get it. If I do, I think I will probably get it worse than most healthy 62 year olds but I will hopefully get over it without any serious effects.

    I hope this helps,

    Angie (Stage 3 melanoma patient)

  • Hello NatalieJane583, 

    You might be interested in reading our information on coronavirus and cancer which you can find on this page. Don't hesitate to give our nurses a call on this free number 0808 800 4040 and talk things through with them as it might help you feel a little bit less worried about it - their line is open Monday to Friday from 9am to 5pm. 

    Best wishes, 

    Lucie, Cancer Chat Moderator

  • Thank you Angie for taking the time to read my post, and for your time in responding. It is a worrying time, and I think everyone is trying to take practical steps, minimise risks, and keep a sense of perspective on things. Your words and sharing your own experience are really valued and appreciated.

    Thank you again <3

     

    Natalie

  • Hello... I was diagnosed with stage 3 breast cancer 16 years ago, underwent mastectomy, reconstruction, chemo, radio therapy and a year of Herceptin. I was told all of my lymph nodes under my right armpit were removed. The sentinal showed signs of cancerous cells. I have since been healthy and well.

    However, I am concerned that I am not on a register at my GP's as having a compromised immune system, and therefore have not had even my 4th booster covid jab. I was told 16 years ago that  I would always have a weakness with regard to fighting infections, which has definately proved to be the case over the years, despite always having  a flu jab. I recently had communications from my GP, who said that after this amount of time my system would have recovered, and therefore I was not at risk. I work as a volunteer in many care homes, and feel I should be able to have the Autumn booster as soon as possible.

    Your thoughts please????? kind wishes

  • Hi,

    As you can see from my reply above, I am a Stage 3 patient (melanoma rather than breast cancer). I'm now 13 years with No Evidence of Disease (the melanoma equivalent of remission). I also know many Stage 3 & 4 melanoma patients. Myself and my fellow Stage 3 patients have not been called for the 4th booster unless they are currently on immunotherapy or targeted therapy. However, all my Stage 4 patient friends are eligible for the booster as they are on drug therapy indefinitely and this alters their immune system.

    My post above explains about node removal and how it doesn't make you immune compromised unless also having chemotherapy (or had it very recently). I think that, your chemo and node removal having been so long ago, your GP won't class you as immune compromised.

    Ironically, I have been called for the booster and flu jab next month because I reach 65 very soon! 

    Angie x