Hello Lindhs
I'm sorry to hear that your wife has been experiencing worsening side effects as her treatment has progressed. I think that lots of members here will have had similar experiences albeit with different drugs and regimes. 
Have you mentioned this to the team responsible for her care? If not then please do let them know so that they can make any adjustments or offer support as appropriate. 

If you'd like to speak to one of our nurses for some advice then you're welcome to call them. They're available on 0808 800 4040, Monday to Friday 9am to 5pm. 

Best wishes, 
Jenn
Cancer Chat moderator