this is a very belated reply to your original post. I have just become a member of this forum and was staggered that my exact problems should be here in  print. I have been suffering with intense leg pains since heart surgery in April 2024. I was diagnosed with prostate cancer 3 years ago and was on watchful waiting or something like that. After 12 months it was decided that my best way forward was hormone therapy followed by radio therapy. I had the first Zoladex implant and two weeks later had my first heart attack ( a serious reaction to Zoladex) I had a double bypass op and was eventually discharged with a long list of medications. Over the last 7 months I have been suffering the most excruciating leg pains and quite often fall over in agony, screaming with pain. GP sent me for physio, physio wouldn't touch me because the pain was in both legs and my back and they were concerned I might have cauda equina syndrome which physiotherapy would exacerbate. I waited a few months and received an appointment to see a neurologist who suggested that I put my trust in the physio team since a recent MRI scan showed no sign of cauda equina syndrome. Neurologist said he will see me again in two months.

I spend 20 minutes a day looking for answers to this painful problem and today Googled "Zoladex, prostate Ca patient, excruciating leg pain"....BINGO. ....and here I am.

Within an hour i followed link after link and discovered that my heart attack is likely to have been caused by the Zoladex implant ( three weeks after having it). Then I went through my extensive list of medications prescribed after the heart surgery and found  " calcium channel blocker,cranberry juice,Pregabalin,and Atorvastatin" a prescription cocktail capable of causing death. The Pregabalin I discontinued after 4 weeks because it made my legs feel like I had broken several bones rather than helping to eliminate pain.

I spoke to my GP and told him what I had read and that I was stopping the Atorvastatin for 2 weeks. I only had two Zoladex jabs at three month intervals . My GP was very understanding and agreed that I should cease the statin..." you're on the maximum doseage , 80 mm, and if you were likely to have a severe reaction such as  leg cramps and possible muscle damage it would be  caused by the maximum doseage."

I don't know where to go now with this information if it proves to be right and the omission of Atorvastatin rectifies my pain problems but somebody in authority needs to bring this to the attention of those who freely write prescriptions so that it doesn't happen to anyone else . I have  fingers crossed but pretty sure that I will be able to walk normally again in the near future. Thanks for reading this and may I wish a Happy and Healthier New Year to all here.

this is a very belated reply to your original post. I have just become a member of this forum and was staggered that my exact problems should be here in  print. I have been suffering with intense leg pains since heart surgery in April 2024. I was diagnosed with prostate cancer 3 years ago and was on watchful waiting or something like that. After 12 months it was decided that my best way forward was hormone therapy followed by radio therapy. I had the first Zoladex implant and two weeks later had my first heart attack ( a serious reaction to Zoladex) I had a double bypass op and was eventually discharged with a long list of medications. Over the last 7 months I have been suffering the most excruciating leg pains and quite often fall over in agony, screaming with pain. GP sent me for physio, physio wouldn't touch me because the pain was in both legs and my back and they were concerned I might have cauda equina syndrome which physiotherapy would exacerbate. I waited a few months and received an appointment to see a neurologist who suggested that I put my trust in the physio team since a recent MRI scan showed no sign of cauda equina syndrome. Neurologist said he will see me again in two months.

I spend 20 minutes a day looking for answers to this painful problem and today Googled "Zoladex, prostate Ca patient, excruciating leg pain"....BINGO. ....and here I am.

Within an hour i followed link after link and discovered that my heart attack is likely to have been caused by the Zoladex implant ( three weeks after having it). Then I went through my extensive list of medications prescribed after the heart surgery and found  " calcium channel blocker,cranberry juice,Pregabalin,and Atorvastatin" a prescription cocktail capable of causing death. The Pregabalin I discontinued after 4 weeks because it made my legs feel like I had broken several bones rather than helping to eliminate pain.

I spoke to my GP and told him what I had read and that I was stopping the Atorvastatin for 2 weeks. I only had two Zoladex jabs at three month intervals . My GP was very understanding and agreed that I should cease the statin..." you're on the maximum doseage , 80 mm, and if you were likely to have a severe reaction such as  leg cramps and possible muscle damage it would be  caused by the maximum doseage."

I don't know where to go now with this information if it proves to be right and the omission of Atorvastatin rectifies my pain problems but somebody in authority needs to bring this to the attention of those who freely write prescriptions so that it doesn't happen to anyone else . I have  fingers crossed but pretty sure that I will be able to walk normally again in the near future. Thanks for reading this and may I wish a Happy and Healthier New Year to all here.