Hi Margalo, I have had Tamoxifen for 5 years then last year l was changed to Letrozol. In the last couple of months l have developed trigger thumb. It started to become painful so thought l would go to my GP. I explained l was taking Letrozol and of course it was on my records. No connection to any side effects was mentioned to me and he just printed off the information sheet for me to read. Today l suddenly thought it my be a side effect so googled and there we go, it is a side effect on the cancer research web site. So much for going to my GP. I have now booked in for a phone consultation with my actual GP not the one that everyone gets when asking for an appointment. I will be asking if she should be referring me back to my oncologist or go for the steroid injections. Slightly worried that my original appointment was no help at all with the regard to side effects of Letrozol. If it was easy for me to google why didn't the doctor know, especially when l reminded him l was taking this drug! Well l will have to wait and see. In the meantime l feel that my other thumb is starting to click :-(