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Have you experience of intravenous vit C treatment?

I was diagnosed with ovarian cancer in June 2011. To date I have had 5 courses of chemotherapy to control the disease. There seems to be no effective treatment for my condition, and in the last 18 months I have been more often on chemotherapy than off it. Having recently had a shoulder operation, I need a good 3 or 4 months off chemotherapy to enable my shoulder to heal. So I am considering having a course of intravenous high dose vitamin C treatment in the hope of delaying the next relapse of symptoms and need for more chemotherapy. In the absence of so called 'gold standard' clinical trial evidence showing the effectiveness of this expensive alternative treatment, I would very much like to hear from anyone who has tried this treatment, or knows someone who has. What was your/their experience of the treatment, and did you/they get any benefits from it?

  • Hello Caroline_W,

    First of all, a big welcome to Cancer Chat. You have come to the right place for support and to learn from the experiences of others who may be in a similar situation as you.

    There is no clear evidence yet to indicate vitamin C has any benefits for cancer patients. You can read more about the history behind using vitamin C as a treatment on our blog: http://scienceblog.cancerresearchuk.org/2008/08/13/vitamin-c-jab-to-beat-cancer/ 

    Looking at the bigger picture since this post was written, more research and clinical trials have been carried out to try and determine the effectiveness of high dose vitamin C as a cancer treatment. The results have been very mixed, with some research showing it can boost the power of cancer drugs when tested on cells grown in a lab or in animals: http://www.ncbi.nlm.nih.gov/pubmed/24266867

    But other studies tell a different story and suggest vitamin C could interfere with some cancer treatments. For example, scientists recently showed it might protect breast cancer cells from the drug tamoxifen: http://www.ncbi.nlm.nih.gov/pubmed/24266867

    Most of the clinical trials studying high dose vitamin C treatment are still at an early stage (phase I) and have only included small numbers of people. The few phase I trials that have finished and have results available looked at the safety and side effects of combining vitamin C with standard treatments for patients with cancers including pancreatic, breast, and multiple myeloma.

    In most cases adding vitamin C to treatment was safe and caused few, if any side effects. However, one clinical trial where vitamin C was given alongside a particular chemotherapy drug had to be stopped early due to side effects and the cancers growing more aggressively, so there are signs that it is not safe for all cancer patients: http://www.cancer.gov/cancertopics/pdq/cam/highdosevitaminc/healthprofessional/page1/AllPages#Reference5.18

    Because the trials have been small and focused on determining the safety of vitamin C, there is little evidence that it has any benefits yet. Some studies found that adding vitamin C alleviated some of the side effects experienced by patients undergoing treatment, but due to the small numbers involved and the way some of these trials were carried out, the evidence is far from solid

    And critically, there is certainly no evidence as yet from any clinical trial that vitamin C improves survival rates. Any potential benefits high dose vitamin C may have as a cancer treatment are still unclear. More research and further clinical trials are needed to determine if it really does improve quality of life for cancer patients, or help people live longer. More importantly, doctors need to find out if it interferes with some anti-cancer drugs, and whether it should only be used to treat certain types of cancer.

    Hope that this helps.

    Best wishes,
    Lucie, Cancer Chat Moderator

  • Hello Lucie and thanks for your reply to my post and the references.   Most of the research seems to be into the effectiveness of IV vitamin C in conjuction with conventional chemotherapy, rather than as a stand-alone treatment as I am considering.  The main current protagonist of IV vitamin C at the Kansas hospital in the USA only offer it in conjuction with chemotherapy. So far, I havent found anybody who has had IV vitamin C, but I'll continue my enquiries a bit longer.  Caroline