It has been a few months since I had last posted anything on the Cancer Research website about my wife’s ovarian cancer diagnosis in Feb 2024. Unfortunately, her condition is not curable but still remains treatable which has had a significant impact on her mental health. In summarising, her first line of treatment was successful and put the cancer into remission and the CA125 levels remain about 9 for about 6 months until the end of 2024. However, the start of 2025 saw her symptoms return with ascites which had required a hospital admission and have an abdominal drain fitted in addition to having a long term catheter that is continuing to cause issues to this day as the tumour had been pressing on her bladding She had restarted the second round of chemotherapy using Gemcitabine and Carboplatin which again appears to have got the situation under control but her CA125 levels have started to creep up again. However, she has had no other symptoms of ovarian cancer and although she is about to have another CT scan, her oncology doctor does not seem that concerned about it which he had previously said that the remaining hard lump in her lower abdomen was more likely caused by inflammation. There is also the possibility that the GemCarbo has worked and killed the cancer cells and the dead cells might be releasing the CA125 protein into her blood hence the rise of the levels (it has never been a reliable marker to determine outcome but something that would warrant a further investigation). It is possible that she may be offered an operation to remove the dead tumours but could also be put on a PARP inhibitor for the foreseeable future. The main issue that I am concerned about is her mental health where she has really struggled since the end of last year and is putting a significant strain on our marriage and her immediate family. However, her clinical nurse did tell me that she is nowhere near the end of life stage.