TNBC Chemo not working

Hi guys,

New here, i was diagnosed with tnbc in jan 2024, started weekly carboplatin and paclataxel aswell as 3 weekly immunotherapy, had CT scan the other week and oncologist says its not working, tumors have grown slightly so dont seem to be reacting.

She recommended surgery for masectomy (possibly double as awaiting genetic testing results) followed by treatment of sorts after pathology results.

Super nervous, please can someone tell me this has happened before and its not super rare to happen.

Any advice or experience info would be great, thankyou

  • Welcome to our forum, sweethart.

    I'm sorry to hear abour your experience. Facing a diagnosis like TNBC can be overwhelming, especially when treatment plans don't go as expected so it's completely normal to feel anxious about what lies ahead.

    What you're experiencing is not uncommon, many others have faced similar challenges with their treatments and I hope some of those here who can relate to what you're going through will be here shortly to chat with you and offer support. In the meantime it's essential to stay connected with your healthcare team and trust in their expertise as they guide you through the next steps.

    Remember to take things one day at a time and be kind to yourself. You're doing the best you can in a challenging situation, and that's incredibly brave.

    Wishing you strength and resilience as you navigate this time,

    Renata, Cancer Chat Moderator

  • Hi Sweethart.

    How are you doing since you posted your message?  Did you have surgery  and how are you feeling /recovering? I can totally relate to the nervousness you felt with the news that the chemo wasn't working.  You are the first person I have found that has experienced what I have experienced re chemo failure. I also found an aggressive TNBC tumour in January 24. I had 11 weeks of carbo and paclitaxol , and when it was realised that my 2cm tumour had grown to 6.5cms  instead of shrunk  - I was given one dose of AC ( which may or may not have worked) . My instinct tells me it didn't work but my instinct also counts for nothing in this situation it seems.  I also had 2 rounds of immunotherapy but this was a late addition as I have autoimmune health issues and was suppressing my immune system medically. Not sure what immunotherapy has bought to the party , if anything 2 treatments in but prepared to have further rounds. 

    I had a lumpectomy in June with wide margins taken and I am currently 'cancer free' . My recovery has been good, my lymph nodes are clear and it was confirmed that the cancer had grown but not spread. I'm so relieved that it was a success , as it was pointed out that the operation could be the only option available after the chemo failed. I start 3 weeks of radiotherapy next week and then immunotherapy. My Oncologist  and MDT want me to go back onto chemo after that , but I believe it is pointless as I'm certain  it completely failed. TNBC is scary and I know reoccurrence stats are not great, but chemo destroyed me - all risk ,no benefit in the end. I have been looking for other folk that are in my position and what  was their medics opinions were  post op re chemo ? did they do  adjuvent chemo? was it the right decision? if they didn't do chemo again - how did that go? I have found no one else yet.  I feel in a scarily unique situation, and it's bittersweet that I have found you . 

  • Hi Sweethart.

    How are you doing since you posted your message?  Did you have surgery  and how are you feeling /recovering? I can totally relate to the nervousness you felt with the news that the chemo wasn't working.  You are the first person I have found that has experienced what I have experienced re chemo failure. I also found an aggressive TNBC tumour in January 24. I had 11 weeks of carbo and paclitaxol , and when it was realised that my 2cm tumour had grown to 6.5cms  instead of shrunk  - I was given one dose of AC ( which may or may not have worked) . My instinct tells me it didn't work but my instinct also counts for nothing in this situation it seems.  I also had 2 rounds of immunotherapy but this was a late addition as I have autoimmune health issues and was suppressing my immune system medically. Not sure what immunotherapy has bought to the party , if anything 2 treatments in but prepared to have further rounds. 

    I had a lumpectomy in June with wide margins taken and I am currently 'cancer free' . My recovery has been good, my lymph nodes are clear and it was confirmed that the cancer had grown but not spread. I'm so relieved that it was a success , as it was pointed out that the operation could be the only option available after the chemo failed. I start 3 weeks of radiotherapy next week and then immunotherapy. My Oncologist  and MDT want me to go back onto chemo after radiotherapy too , but I believe it is pointless as I'm certain  it completely failed. TNBC is scary and I know reoccurrence stats are not great, but chemo destroyed me - all risk ,no benefit in the end. I have been looking for other folk that are in my position and what  was their medics opinions were  post op re chemo ? did they do  adjuvent chemo? was it the right decision? if they didn't do chemo again - how did that go? I have found no one else yet.  I feel in a scarily unique situation, and it's bittersweet that I have found you .