Hi,

I'm looking for some suggestion regarding my close relative currently not in UK. He’s 44 years old, diagnosed with Metastatic Non-small cell carcinoma, Adenocarcinoma with foci of squamous diff in March 2023.

The treatment started with 1 session of Chemotherapy (INJ. PEMETREXED + INJ. CARBOPLATIN) and then followed by Tab. Osimertinib (Tagresso) 80mg I Daily Since April 2023.
However, the next PET scan done in June has showed mixed response. While the primary lung mass is marginally increased (SUV reduced) and there are few new lesions, some of the lymph nodes have reduced in size and are now with 0 SUV.

The current oncologist believes this as progression and would like to stop Tab. Osimertinib (Tagresso) and continue with Chemotherapy and has suggested Liquid biopsy to identify new mutations. He’s now planned for chemotherapy with INJ. PEMETREXED + INJ. CARBOPLATIN + INJ. BEVACIZUMAB + INJ. ZOBONE

Has anyone aware of or gone through similar experience of progression with Osimertinib (Tagresso)?

Could someone recommend any private Lung cancer specialist in UK for consultation as he won’t be eligible for 1 through NHS?

Many thanks.