Hello, I know that the posts I have seen on the topic of Exemestane are quite old, but it may still be a revelant topic to some of the chat group. I have taken tamoxifen, arimidex and currently exemestane, which I have taken for 10 years. Unlike the other ladies who posted I have not noticed any significant side effects except occasional hot flushes. I am now 75. I don't know if that makes a difference in my reactions. But for all you ladies (or gents) on exemstane or about to be prescribed it, remember that although some people have really horrid side effects others do not.