Hi Claire,

Welcome to Cancer Chat. I'm sorry to hear you've been experiencing difficulties with this. This is a very personal decision, and it's also always wise to consider advice from your doctor before changing anything. If you haven't already, do talk things through with them just to double check you have all the info and options you need.

This topic has come up on the forum several times - so hopefully you'll receive further replies to your post soon, but if not then it might be worth searching the forum (using the button in the blue bar above) to find other relevant discussions.

WIshing you all the best,

Ben
Cancer Chat Moderator

Hi Ben,

I've searched extensively for this and found nothing - lots of people are having bad experiences with letrozole but I can't find anything about anyone premenopausal coming off it early.

thanks

claire 

Hi 

Slightly related perhaps, but there is a webinar on the Kidney cancer UK website about trials and one of the trial metrics was the time people spent off drugs, either inbetween immunotherapies, or just on the "no drugs" part of the therapy schedule.  If I remember correctly, it was to see if there was a difference in outcomes between having a break from the drug and the side effects, and taking it continually.  It might have included people who had to stop the treatment because they couldn't tolerate it any more - a frequent event with kidney cancer I believe.   But it was not for the drugs you mention and it sounds like a different cancer too.  I can't find the link right now, but can dig it out?  
Claire

Hi Claire

Please can i ask - did you come off zoledex? I am having the same issues as you, gained weight during covid and treatment but despite eating better and moving more it will not come off and it mainly sits arouns my mid section making me look bloated / pregnant. 

Although my type of Breast Cancer was not hormone related I have been on zoledex now for 18 months as a preventative.

Hope u had a lovely wedding x

  Good ole cancer its certainly the gift that keeps giving.  Like you I have been taking Letrozole with Zoladex, on top of bone issues I did a really stupid thing today and weighed myself .  I admit I haven't been particularly active mostly due to bone pain but have been walking when I can, and use the stairs at work.  I felt rubbish today, my partner bless him said " well I'd rather you gained weight than not being here" which I do get & being realistic is true but I hate it.  Its bad enough going through 9 months of treatment but now this!  I'm sorry for ranting but I know you will understand & know that you are not alone.

Bolly xx