I experienced excrutiating pain after my first cycle of taxol on 2nd August .(also had carboplatin & avastin)The nurses at the clinic were very surprised I had so much pain as they told me patients usually only have some moderate discomfort.Believe me this was unbearable.No pain killers seemed to touch it .I tried everything.Liquid morphine,oxycodone with paracetamol, hot baths,hot water bottles.GP surgery suggested ibuprofen although I'm not supposed to take it The pain started in my toes & feet &spread to my ankles,legs &hip joints.It was especially severe at night in bed & as a result I had 3 sleepless nights which just added to my general exhaustion &malaise .I have asked my cancer nurse to contact my oncologist & see if my next dose,can be reduced with affecting the efficacy of the treatment I think the amount I had was just too toxic for my body Anyone else suffered extreme side effects like this?