Hi Jason The radiotherapy will make you tired, you might get through the first batch of treaments and continue working, but the last two weeks and the two weeks after it is finished you may not feel like doing much. your body will be using all your energy to repair itself and you will be struggling to eat enough as your throat and mouth will be very sore. I cant comment on the chemotherapy but I know it can also make you tired and ill. You need to shift your main concern from work to getting back to good health. I am also self employed and know the predicament you find yourself in. I think there is some financial help available but I recommend that you get your appointed McMillan nurse, if you have one, to help you fill out the paperwork, they know how to word the answers. I did the application on my own and received nothing. I think McMillan can also get you a one off payment to help you out. I dont think many people employed in large organisations appreciate just how fortunate they are in this respect, when it comes to a serious illness. If you need further help post back here as there are several forum members with experience head and neck cancer. Wish you lots of strength getting through your treatment, Kim