Early BC and Positive SLNs ONCOTYPE Dx

Hello:) A quick summary of my situation:

I'm 58, fit, very healthy diet and exercise, weight on the low side. Stopped HRT 1 month ago (had early menopause at 33, so had taken it for a very long time!).

Had a supposedly sebaceous cyst (biopsy normal 5yrs ago, but decided to have it removed now) removed the area where the breast meets the axilla (left side)in August which turned out to be grade 2 invasive BC (10mm tumour), ER 8/8, PR  8/8, HER-2 negative. Second surgery end of September showed clear margins and 2/4 positive sentinel lymph nodes. One node was 10mm diam and had 3mm macrometastasis, other node 7mm with 6mm macrometastasis (no ECT in both). 

I was immediately told the next step would be an axillary clearance,  however,  it seems that studies are showing that Radiotherapy has very similar outcomes as ALND (and it's an option in the ESMO European guidelines). I have put this to my surgeon who took my case back to the MDT and since then I had 2 meetings with the oncologist. I have asked about the Oncotype test, but he said it would not be validated as I decided not to have ALND and we don't know the nodal status. I have called Oncotype DX company and was told I could still have the test privately and didn't need the results of ALND and could compare my case with others in the database.

As I didn't want to have the ALND, the oncologist suggested that I could have chemotherapy if I wanted, something he had only mentioned in the context of Oncotype score results in our first meeting. As I don't know if I would benefit from chemo, I declined and I'm going for RT, which will be given to the breast, axilla and supraclavicular fossa (which also worries me...), towards the end of November. 

Is anyone in a similar situation? I wonder about a second opinion and whether it's worth getting the Oncotype test privately, which would mean asking the hospital to order it and send a tumour sample.  I think it might give me an idea of recurrence and whether chemo would be an option. Not sure this will help to determine if the collarbone needs RT or not.

 

Lots of questions... thank you for reading! 

Cris

 

  • Hi Cris, 

    I noticed you haven't had a reply just yet so I just wanted to reassure you that your post has been seen and hopefully some of our members who have been in a similar situation will be along soon to offer you their thoughts and advice.

    I can see you've made a post about this in our nurses section of the forum as well. I hope the reply you receive from them next week will help you decide what to do but in the meantime I hope this information I've found about the oncotype test will prove to be useful.

    We're thinking of you Cris and wishing you all the best with your radiotherapy at the end of the month.

    Kind regards,

    Steph, Cancer Chat Moderator

  • Hi Steph,

    Thanks for your help and support :):)

    I had already looked in the Breast Cancer Now website. It does indicate that it might be useful for me with 2/4 positive nodes, since it can be used for people with up to 3 positive nodes. However, what's always missing is whether the 3 nodes are sentinel or from axillary clearance.

    Warm regards,

    Cris