Immuno theraphy and extreme fatigue

My wifes history , 2 lots of breast cancer 10 and 5 years ago , 3 years ago kidney cancer kidney removed ,2 years ago metastases in tibia rpaired and plated but with inert filler  not part of normal scanning fter kidney cancer , enlarged lymph nodes in chest,.terminal diagnosis  then two drug treatment by immunotherapy reducing to one drug . 

my inteligent artistic wifes life has been reduced to the sofa and tele, she cannot concentrete , sleeps most of the time  cant stand long enough to make herself tea. an extended life but no life.

last dose of immunotherapy three months ago ..

Has any one had the symptoms of extreme fatigue lessen over time ? after immunotherapy