Hi, my name is Denise and my husband of 43 years was diagnosed with lung cancer last year. He had an operation, chemo and radiotherapy and thought it had all been successful However he started suffering headaches a couple of months ago and was diagnosed with secondary cancer to the brain. He has been told he cannot be cured and they cannot operate but are starting him on a treatment of pembrolizumab this week which he will have every three weeks. He has been on steroids to keep the brain swelling down but they are being decreased from 3 a day, to 2 a day and from tomorrow he will be on one a day for a week. He was also diagnosed two weeks ago with a massive blood clot on his lung for which he is injecting every day. I have noticed a severe change in his mood which I am led to believe is the reduction of the steroids. His behavour and mood are completely out of character. Has anyone else experienced this, if so, how long does it take to subside?