Undiagnosable cancer - has anyone else been in this position before? How did you cope?

My younger brother got diagnosed with cancer this August. Thankfully according to doctors it’s supposed to be a recently developed tumour however they’ve done a biopsy and removed his kidney where the tumour was located and they cannot figure out what type of cancer it is other then it being kidney cancer. It’s been to different hospitals and the European board but they still don’t know what it is exactly. Apparently that doesn’t usually happen and even his doctor has said she’s never experienced that before. I was wondering if anyone else has had similar experiences and how that went, how people dealt with it and not having an answer or a clear plan on what to do. Thanks