My husband is just starting a course of Capecitabine for colon cancer.  The instructions are to take it twice a day, 12 hours apart, within 30 minutes of a meal.  We normally have breakfast at 9am then eat our evening meal around 7pm, this would be periods of 10 hours in the day and 14 hours overnight.  Does anyone know if this is safe or are the 12 hour periods to be strictly adhered to.