My wife was diagnosed with stage 3 metastatic bowel cancer with tumours on her liver 15 months ago. She had one round of chemo then 7 months of 3 weekly Pembrolizumab (Keytruda). She developed shingles in mid-January and then incipient sepsis 3 weeks later at which point the oncologist stopped the immunotherapy. She then had a bowel resection and liver surgery 3 apart, in mid-March and early June respectively. Throughout her treatment, my wife has suffered severe fatigue which has become very much worse since the cumulative effects of 2 lots of anaesthesia. She is now chronically fatigued and suffering from general memory loss, with her short term and prospective memory being particularly bad. She has also suffered a couple of ‘absent’ episodes and has also experienced various visual/migraine effects. Has anyone else suffered in this way and, if so, how long has it lasted and are there any recommendations for alleviating the symptoms?