Neuropathy

Oxaliplatin neuropathy starting early — what can be done?

My husband is receiving CapOx (oxaliplatin and capecitabine) plus trastuzumab (Herceptin) for HER2-positive oesophageal cancer. He has now had two cycles.

After his first treatment, he developed soreness and discomfort in his feet around day 12. After the second cycle, the symptoms appeared much earlier, around day 5. His feet can become red, hot and painful after even a short walk, and he is now noticing symptoms in his fingertips too.

The hospital has examined his feet and said they look fine, but he is definitely experiencing discomfort.

We’re worried that this will progressively get worse with each cycle. What options are there for managing or preventing oxaliplatin neuropathy? Can the oxaliplatin dose be reduced or changed if symptoms are already developing, and does this necessarily mean stopping his cancer treatment?

Could this be neuropathy, hand-foot syndrome from the capecitabine, or possibly a combination of both?

I’d also be interested to hear from anyone who has experienced something similar with CapOx and trastuzumab, particularly whether their symptoms improved after treatment.

  • Hello,

    yes l get the oxaliplatin workover.By cycle 4 l could hardly walk and my hands had difficuty gripping.l was receiving treatment on an offshore island with consultant mainland based.Unfortunately he retired and a locum took over who was reluctant to lower the dose. As a result l finished the last two cycles on a full strength dose which left me with neuropathy in both hands and feet.

    The hands recovered after a year, the feet are permanent. It took two years to stop tripping and falling over,and three years for my control centre to stop constantly informing me that they hurt. We have now lived with each other for twelve years and l regard them as the fee for paid up membership of life.

    l had a stage 4 diagnosis ,bowel and liver surgery just in the nick of time, with pre and post chemo and radio,all things considered hitting my invader hard led to a better outcome than the alternative.At the time l felt l was going through misery and to ease back and give the advantage to my foe for the sake of feeling slightly less miserable seemed like a job half done is no job done at all,so no neuropathy or no cancer

    Your husbands timings would match my experience, so yes it would appear to be neuropathy, but for most it will ihave mproved by six months after treatment.Keep your team updated at each cycle

    David