Low psa

Hi my husband was diagnosed 18 months ago with advanced metastatic prostate cancer, his initial symptom was a pain in his right shoulder his diagnosis came after having a chest xray which showed lung mets and mets in the right shoulder  and following that further tests which then went on to find the primary which was prostate. 

He had six months of chemotherapy which has helped and his psa has remained low currently at 0.27. The issue we have is the constant pain in both shoulders, he had a bone scan in August 2025 which showed no further progression within the shoulder but some mets now within the sacral area but the pain in his shoulders is now worse than ever. His oncologist is convinced that the pain is not cancer related but either orthopedic which has now been ruled out or rheumatoid (which were waiting on a referral to be done).

We're concerned that despite his psa being low his pain could be cancer related within the shoulder as this is how he first presented and that our oncologist doesn't feel that there could be any further spread as his psa is low and that is all he keeps saying to us. 

  • Hello Keels01. and thank you for posting,

    I’m sorry to hear about your husband’s situation. This must be a very worrying time for both of you.

    As we’re not involved in his care, we can’t say for certain what’s causing the pain, but I can appreciate that this is unsettling, especially as it feels similar to when he was first diagnosed. It’s reassuring that his PSA remains low, as this usually suggests the treatment is working.

    With the pain continuing, it may help to speak with your husband's specialist nurse (CNS) if he has one, as they know his history and may be able to give him some advice. You mentioned rheumatoid arthritis is being considered, which is worth exploring, but if you still feel unsure, asking for a second opinion from another oncology team can sometimes provide clarity.

    Please feel free to get back to us. If you’d like to talk things through with one of our nurses, please call our free helpline on 0808 800 4040, Monday to Friday, 9am–5pm.

    Jemma