I have been on Zoladex and Anastrozole for 4 years and am due to switch to Tamoxifen in mid 2026. Please could I have a bit of information about these differences and any changes in side effects anyone may have experienced? 

 The Zoladex and Anastrozole have been hell and has left me with a massive amount of weight gain which doesn’t go away despite trying many methods, and treatment resistant depression which has been awful. Alongside many other horrible side effects which nobody offers any kind of support for. I’ll then be on Tamoxifen for another 5 years.