My stepfather has been diagnosed with CUP. A metastasis in his humerus fractured the bone and he waited months before anything was done. He ended up with an intramudallary nail but since the tumour has grown excessively. He has nodules in several parts of his body and recently started radiotherapy. He is unsure whether to have chemotherapy. Drs are keen for him to start but it is not guaranteed to do anything. We totally respect his decision but wanted to know if others had found chemo for CUP effective in relieving symptoms and controlling growth?