Brachytherapy Fatigue

I had brachytherapy treatment in February 2025. I have since been monitored and recently had a PSA blood test that returned normal (although I am yet to discuss this with the hospital).

However, an initial period of extreme fatigue and dizziness has now progressed to just the fatigue (with pains and tingling in legs and arms). The team dealing with me seem surprised by this and have been adjusting my Tamsulosin medication, and Amlodipine I receive for high blood pressure. I did a quick search through posts but found it difficult to isolate those referring to brachytherapy. I'm finding the fatigue persistent and difficult to manage, sleeping for long periods and becoming tired quite quickly during the day. I continue to be quite incontinent but this is slowly improving, I hope.

I assume this is an issue that will correct itself but I am finding quite a lot of pressure to 'pull myself together'. Is this a normal side effect and how long will it last? The Tamsulosin leaflet says that asthenia is a known but uncommon side effect.

  • Hello and thanks for posting

    I'm sorry to read about your situation. This must be a difficult time for you.

    Fatigue after brachytherapy is common and can last for some time. Some men do gradually regain their energy within a year or so after treatment, especially as urinary side effects settle down.

    On top of that both tamsulosin and amlodipine can cause tiredness, dizziness, or weakness in some people. Tamsulosin does list asthenia ( general weakness ) as a possible side effect.

    We have some information on our website about fatigue and tips on how to manage it such as doing a form of gentle exercise, getting enough rest and eating a good diet. Macmillan Cancer Support has some further information on fatigue.

    It might be a good idea for you to keep a fatigue diary. This can help you keep a record of how you are feeling, and how your energy levels change and can show patterns of your fatigue. This can help plan your day. It can also highlight which activities makes you feel better or worse.

    Sometimes there is a specific medical cause for which there might be a remedy such as anaemia, thyroid changes, or vitamin deficiencies so do get some input about this from your doctors or specialist nurse about this.

    More importantly, please don't feel you have to 'pull yourself together'. Recovery takes time and with the right adjustment and support, most people do improve.

    I hope this is of some help. Please get back to us if you need any more information or support. You may find it helpful to talk things through with one of the nurses on our helpline. The number to call is Freephone 0808 800 4040 and the lines are open from 9 am till 5 pm, Monday to Friday.

    Kind regards,

    Celene