Hi there, since Mike's diagnosis nearly three years he started chemotherapy and until last month his PSA remained well within the normal range. HOwever the latest PSA was 2.6 which necessitated a bone and ct scan.  The results were not good which showed a new intra-abdominal lymphadenopathy suggesting disease progression. Mike will start on Enzalutamide tomorrow , however he is now having some pain in his right side at the lower end of the back. Its not bad enough to take pain relief. Mike is a very active 83 year old, he continues to play tennis twice a week and badminton once a week. My concern about the pain is worring me - will the Enzalutamide help keep the cancer cells stable. I am completely worried and just need some answers please. I know the cancer is spreading but what is the prognosis?.