Capecitabine and blisters

My wife has breast cancer which has got into her spine and other bones.  Her main treatment is Capecitabine and she is doing great except for dryness on her hands, feet and lips.  But now she has a blister the size of Wyoming on her foot making walking painful.  Is this a known side effect?  What can we do about the blisters please as she has never suffered from them before.  She is moisturising like crazy and I now have blister patches for her but we need to keep her active.  Thank you.