Histology help Lung adenocarcinoma

Hi, mum has asked me to ask if you can help us understand what this means please. 

Detection of EGFR variants, c.2573T> G p. (Leu858Arg) and c.2500G>t p. (Val834Leu)

Stage pT2b, NO RO

Mum had robotic upper lobe segmentectomy & left mediastinal nodal dissection. (6cm Lung adenocarcinoma.) mid March.

Despite having PET scans she has been put on the list for a head CT as this is the only area they hadn't looked at.

She's been prescribed Osimertinib to take one tablet for approximately 3 years. 

We are very pragmatic about this all and consider ourselves very lucky she had a pulmonary embolism last year that found the nodule! My mum is a warrior!

Thank you so much for being here for all of us x

Parents Reply Children
  • hi peppa14

    sorry to read this about your mum’s diagnosis. 
    I too have had lung surgery ( twice - 6 years apart and on both lungs) and Iv just finished chemotherapy for my latest cancer. 
    I can’t help with your main question about what that means as I’ve no medical knowledge 

    however a similar text on my own tumour biopsy post surgery related to the chemo treatment I was going to receive to “ mop up” any missed cells so this may be the case for your mum and this I could be what this relates to, but I could be wrong and it could relate to the type of cancer itself and it’s makeup

    Mine was

    T3 multi focal same lobe N0 adenocarcinoma non small cell lung cancer, EFFR negative,PD-L1 1-2%

    may be best to call one of the doctors/nurse team looking after your mums care who will no doubt be able to answer your questions

    I do hope you can get some clarification on everything and wish your mum well with her treatment 

    take care x

  • Sorry having looked at it again I’m almost sure it relates to the make up of the cancer as it states EGFR variants and what follows are possibly the different variants identified but do check with nurse practitioners who will help you understand more about this 

    pT2   ? Primary tumour stage 2 ?

    N0.    ? No lymph node involvement?

    R0.    ? Unsure? 

  • Thank you Hutchi for your reply, I really appreciate it. I wish you every success in your recovery x